G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca
| Uniprot primary ID | P28223 |
| PDB ID | |
| DrugBank ID | DB00751 DB00777 DB06148 DB01142 DB01049 DB01624 DB01622 DB01069 DB01149 DB01621 DB04842 DB00933 DB06288 DB00875 DB00502 DB01239 DB01238 DB00679 DB00934 DB00409 DB00408 DB00370 DB01403 DB00540 DB00420 DB00589 DB00321 DB08815 DB00458 DB00246 DB00543 DB00656 |
| BioGrid ID | 109588 |
| GuidetoPHARMACOLOGY ID | 6 |
| PharmGKB ID | PA193 |
| KEGG ID | hsa:3356 |
| BioCyc | |
| Entrez Gene (Gene ID) | 3356 |
| DIP | DIP-41844N |
| STRING | 9606ENSP00000367959 |
| MINT | MINT-443877 |
| IntAct | |
| DMDM | 543727 |
| BREDNA | |
| Rectome | R-HSA-390666 R-HSA-416476 |
| SignaLink | P28223 |
| BindingDB | P28223 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.793 | 0.867 | 0.792 | 0.791 | 0.793 | 0.798 | 0.875 | 0.796 | 0.799 | 0.793 | Download |
| MACCS fingerprints | 0.761 | 0.824 | 0.749 | 0.796 | 0.702 | 0.771 | 0.836 | 0.758 | 0.818 | 0.698 | Download |
| Daylight fingerprints | 0.759 | 0.833 | 0.775 | 0.706 | 0.845 | 0.763 | 0.846 | 0.776 | 0.718 | 0.835 | Download |
| ECFP2 fingerprints | 0.854 | 0.928 | 0.849 | 0.877 | 0.821 | 0.862 | 0.938 | 0.857 | 0.888 | 0.825 | Download |
| ECFP4 fingerprints | 0.872 | 0.943 | 0.874 | 0.859 | 0.889 | 0.877 | 0.948 | 0.878 | 0.864 | 0.892 | Download |
| ECFP6 fingerprints | 0.858 | 0.936 | 0.864 | 0.822 | 0.906 | 0.867 | 0.942 | 0.871 | 0.834 | 0.908 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
All rights reserved.
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E-mail: biomed@csu.edu.cn
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