G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca
| Uniprot primary ID | P28335 |
| PDB ID | |
| DrugBank ID | DB00777 DB06148 DB01142 DB01049 DB00321 DB01149 DB00734 DB00934 DB01191 DB01239 DB01238 DB00408 DB00370 DB01403 DB00540 DB00543 DB00589 DB01151 DB06216 DB00334 DB01392 DB00726 DB00805 DB06144 DB09014 DB01200 DB01267 DB00458 DB00413 DB00246 DB00420 DB00656 |
| BioGrid ID | 109590 |
| GuidetoPHARMACOLOGY ID | 8 |
| PharmGKB ID | PA194 |
| KEGG ID | hsa:3358 |
| BioCyc | |
| Entrez Gene (Gene ID) | 3358 |
| DIP | |
| STRING | 9606ENSP00000276198 |
| MINT | MINT-443944 |
| IntAct | P28335 |
| DMDM | 112816 |
| BREDNA | |
| Rectome | R-HSA-390666 R-HSA-416476 |
| SignaLink | P28335 |
| BindingDB | P28335 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.796 | 0.870 | 0.794 | 0.799 | 0.790 | 0.798 | 0.872 | 0.795 | 0.803 | 0.787 | Download |
| MACCS fingerprints | 0.765 | 0.826 | 0.751 | 0.805 | 0.697 | 0.781 | 0.844 | 0.769 | 0.826 | 0.712 | Download |
| Daylight fingerprints | 0.760 | 0.829 | 0.776 | 0.705 | 0.848 | 0.757 | 0.829 | 0.774 | 0.699 | 0.850 | Download |
| ECFP2 fingerprints | 0.851 | 0.927 | 0.847 | 0.871 | 0.822 | 0.856 | 0.935 | 0.851 | 0.879 | 0.822 | Download |
| ECFP4 fingerprints | 0.871 | 0.942 | 0.872 | 0.857 | 0.887 | 0.873 | 0.947 | 0.873 | 0.866 | 0.881 | Download |
| ECFP6 fingerprints | 0.858 | 0.936 | 0.863 | 0.821 | 0.906 | 0.869 | 0.942 | 0.872 | 0.838 | 0.907 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
All rights reserved.
The recommended browsers: Safari, Firefox, Chrome,IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |