Details-Calcnet-AlzheimerNet

Target name

P29466: Caspase-1

Protein function

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

Database links

Uniprot primary ID	P29466
PDB ID	1BMQ 3D6H 1ICE 3NS7 2H48 1SC4 1SC1 1SC3 2FQQ 2HBY 2HBZ 2H4Y 2H4W 2HBQ 2HBR 1RWX 3D6F 1IBC 3E4C 1RWP 3D6M 1RWV 1RWW 1RWK 1RWM 1RWN 1RWO 2H51 2H54
DrugBank ID	DB01017
BioGrid ID	107284
GuidetoPHARMACOLOGY ID	1617
PharmGKB ID	PA26083
KEGG ID	hsa:834
BioCyc
Entrez Gene (Gene ID)	834
DIP	DIP-175N
STRING	9606ENSP00000410076
MINT	MINT-201196
IntAct	P29466
DMDM	266321
BREDNA	342236
Rectome	R-HSA-844623 R-HSA-844615 R-HSA-448706 R-HSA-168638 R-HSA-844456
SignaLink	P29466
BindingDB	P29466

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.871	0.892	0.873	0.879	0.866	0.899	0.908	0.901	0.926	0.878	Download
MACCS fingerprints	0.856	0.895	0.856	0.876	0.836	0.875	0.933	0.876	0.904	0.851	Download
Daylight fingerprints	0.841	0.854	0.853	0.791	0.913	0.839	0.866	0.855	0.793	0.912	Download
ECFP2 fingerprints	0.900	0.922	0.896	0.948	0.847	0.913	0.950	0.912	0.978	0.851	Download
ECFP4 fingerprints	0.898	0.914	0.896	0.935	0.857	0.926	0.950	0.926	0.978	0.878	Download
ECFP6 fingerprints	0.890	0.916	0.889	0.908	0.871	0.930	0.947	0.929	0.978	0.885	Download

Download datasets

Positive dataset

Negative dataset