Details-Calcnet-AlzheimerNet

Target name

P29474: Nitric oxide synthase, endothelial

Protein function

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Database links

Uniprot primary ID	P29474
PDB ID	1M9M 4D1O 2MG5 1M9K 1M9J 1NIW 3EAH 2LL7 3NOS 1M9R 1M9Q 4D1P
DrugBank ID	DB00997 DB01110 DB00125 DB00360 DB00155
BioGrid ID	110909
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA254
KEGG ID	hsa:4846
BioCyc	MetaCyc:HS09149-MONOMER
Entrez Gene (Gene ID)	4846
DIP	DIP-38479N
STRING	9606ENSP00000297494
MINT	MINT-106980
IntAct	P29474
DMDM	266648
BREDNA	1141339
Rectome	R-HSA-1222556 R-HSA-203754 R-HSA-392154 R-HSA-203615 R-HSA-203641 R-HSA-1474151 R-HSA-5218920
SignaLink	P29474
BindingDB	P29474

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.532	0.624	0.593	0.636	0.568	0.642	0.687	0.642	0.763	0.555	Download
MACCS fingerprints	0.549	0.620	0.639	0.604	0.660	0.611	0.693	0.658	0.638	0.673	Download
Daylight fingerprints	0.520	0.597	0.594	0.604	0.589	0.533	0.566	0.558	0.600	0.527	Download
ECFP2 fingerprints	0.382	0.550	0.581	0.356	0.710	0.583	0.745	0.684	0.525	0.800	Download
ECFP4 fingerprints	0.499	0.621	0.589	0.564	0.604	0.671	0.769	0.700	0.725	0.682	Download
ECFP6 fingerprints	0.532	0.629	0.600	0.625	0.585	0.678	0.760	0.689	0.775	0.627	Download

Download datasets

Positive dataset

Negative dataset