Details-Calcnet-AlzheimerNet

Target name

P29475: Nitric oxide synthase, brain

Protein function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

Database links

Uniprot primary ID	P29475
PDB ID	4D1N 4UCH 4V3U
DrugBank ID	DB00997 DB03147 DB00155
BioGrid ID	110905
GuidetoPHARMACOLOGY ID	1251
PharmGKB ID	PA252
KEGG ID	hsa:4842
BioCyc	MetaCyc:HS01647-MONOMER
Entrez Gene (Gene ID)	4842
DIP	DIP-40999N
STRING	9606ENSP00000337459
MINT	MINT-122019
IntAct	P29475
DMDM	1709333
BREDNA	1141339
Rectome	R-HSA-1222556 R-HSA-392154
SignaLink
BindingDB	P29475

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.800	0.845	0.798	0.800	0.796	0.837	0.887	0.834	0.840	0.829	Download
MACCS fingerprints	0.741	0.831	0.740	0.735	0.746	0.776	0.850	0.768	0.776	0.760	Download
Daylight fingerprints	0.676	0.662	0.659	0.705	0.611	0.655	0.646	0.638	0.679	0.595	Download
ECFP2 fingerprints	0.827	0.881	0.823	0.837	0.809	0.896	0.941	0.891	0.932	0.848	Download
ECFP4 fingerprints	0.838	0.898	0.836	0.840	0.833	0.898	0.949	0.894	0.920	0.867	Download
ECFP6 fingerprints	0.827	0.898	0.829	0.806	0.853	0.856	0.940	0.856	0.846	0.867	Download

Download datasets

Positive dataset

Negative dataset