Details-Calcnet-AlzheimerNet

Target name

P30926: Neuronal acetylcholine receptor subunit beta-4

Protein function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Database links

Uniprot primary ID	P30926
PDB ID	2ASG
DrugBank ID	DB00898 DB00514 DB00674 DB01227 DB01090 DB00184
BioGrid ID	107565
GuidetoPHARMACOLOGY ID	474
PharmGKB ID	PA26496
KEGG ID	hsa:1143
BioCyc
Entrez Gene (Gene ID)	1143
DIP
STRING	9606ENSP00000261751
MINT
IntAct
DMDM	2506129
BREDNA
Rectome	R-HSA-629587 R-HSA-629597 R-HSA-629594
SignaLink
BindingDB	P30926

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.748	0.825	0.746	0.754	0.737	0.741	0.851	0.759	0.625	0.923	Download
MACCS fingerprints	0.734	0.745	0.702	0.825	0.579	0.813	0.885	0.793	0.813	0.769	Download
Daylight fingerprints	0.738	0.723	0.702	0.842	0.561	0.828	0.892	0.828	0.750	0.923	Download
ECFP2 fingerprints	0.613	0.698	0.623	0.596	0.649	0.786	0.952	0.793	0.688	0.923	Download
ECFP4 fingerprints	0.707	0.805	0.746	0.614	0.877	0.828	0.957	0.828	0.750	0.923	Download
ECFP6 fingerprints	0.703	0.812	0.763	0.561	0.965	0.815	0.875	0.828	0.688	1.000	Download

Download datasets

Positive dataset

Negative dataset