Target name

P30926: Neuronal acetylcholine receptor subunit beta-4


  Protein function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

  Database links

Uniprot primary ID P30926
PDB ID 2ASG
DrugBank ID DB00898 DB00514 DB00674 DB01227 DB01090 DB00184
BioGrid ID 107565
GuidetoPHARMACOLOGY ID 474
PharmGKB ID PA26496
KEGG ID hsa:1143
BioCyc
Entrez Gene (Gene ID) 1143
DIP
STRING 9606ENSP00000261751
MINT
IntAct
DMDM 2506129
BREDNA
Rectome R-HSA-629587 R-HSA-629597 R-HSA-629594
SignaLink
BindingDB P30926

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.748 0.825 0.746 0.754 0.737 0.741 0.851 0.759 0.625 0.923 Download
MACCS fingerprints 0.734 0.745 0.702 0.825 0.579 0.813 0.885 0.793 0.813 0.769 Download
Daylight fingerprints 0.738 0.723 0.702 0.842 0.561 0.828 0.892 0.828 0.750 0.923 Download
ECFP2 fingerprints 0.613 0.698 0.623 0.596 0.649 0.786 0.952 0.793 0.688 0.923 Download
ECFP4 fingerprints 0.707 0.805 0.746 0.614 0.877 0.828 0.957 0.828 0.750 0.923 Download
ECFP6 fingerprints 0.703 0.812 0.763 0.561 0.965 0.815 0.875 0.828 0.688 1.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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