Details-Calcnet-AlzheimerNet

Target name

P31645: Sodium-dependent serotonin transporter

Protein function

Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.

Database links

Uniprot primary ID	P31645
PDB ID
DrugBank ID	DB04896 DB00656 DB01142 DB06204 DB00321 DB01149 DB01104 DB00285 DB00289 DB08918 DB01191 DB00408 DB00852 DB06700 DB06701 DB00370 DB06148 DB00540 DB00422 DB00182 DB00543 DB00661 DB01151 DB00215 DB01175 DB01114 DB00726 DB00805 DB01105 DB09016 DB00458 DB00191
BioGrid ID	112423
GuidetoPHARMACOLOGY ID	928
PharmGKB ID	PA312
KEGG ID	hsa:6532
BioCyc
Entrez Gene (Gene ID)	6532
DIP
STRING	9606ENSP00000261707
MINT	MINT-577123
IntAct	P31645
DMDM	400630
BREDNA
Rectome
SignaLink
BindingDB	P31645

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.782	0.839	0.777	0.795	0.759	0.806	0.863	0.797	0.809	0.783	Download
MACCS fingerprints	0.816	0.863	0.802	0.875	0.729	0.830	0.875	0.811	0.889	0.727	Download
Daylight fingerprints	0.686	0.704	0.689	0.678	0.699	0.721	0.730	0.714	0.707	0.723	Download
ECFP2 fingerprints	0.892	0.955	0.888	0.916	0.860	0.913	0.967	0.907	0.933	0.880	Download
ECFP4 fingerprints	0.906	0.961	0.906	0.905	0.907	0.922	0.972	0.918	0.922	0.914	Download
ECFP6 fingerprints	0.889	0.950	0.891	0.869	0.914	0.916	0.969	0.913	0.901	0.926	Download

Download datasets

Positive dataset

Negative dataset