Details-Calcnet-AlzheimerNet

Target name

P32297: Neuronal acetylcholine receptor subunit alpha-3

Protein function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Database links

Uniprot primary ID	P32297
PDB ID	4ZK4
DrugBank ID	DB01156 DB00514 DB00674 DB01227 DB01090 DB09028 DB00898 DB00184 DB01273
BioGrid ID	107558
GuidetoPHARMACOLOGY ID	464
PharmGKB ID	PA113
KEGG ID	hsa:1136
BioCyc
Entrez Gene (Gene ID)	1136
DIP
STRING	9606ENSP00000315602
MINT
IntAct	P32297
DMDM	254763435
BREDNA
Rectome	R-HSA-629587 R-HSA-629597 R-HSA-629594
SignaLink
BindingDB	P32297

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.791	0.831	0.803	0.746	0.861	0.889	0.911	0.918	0.800	1.000	Download
MACCS fingerprints	0.707	0.770	0.721	0.672	0.770	0.681	0.792	0.754	0.640	0.833	Download
Daylight fingerprints	0.721	0.726	0.717	0.730	0.705	0.760	0.843	0.803	0.760	0.833	Download
ECFP2 fingerprints	0.795	0.821	0.799	0.779	0.820	0.851	0.888	0.885	0.800	0.944	Download
ECFP4 fingerprints	0.821	0.860	0.828	0.787	0.869	0.870	0.869	0.902	0.800	0.972	Download
ECFP6 fingerprints	0.784	0.852	0.803	0.713	0.893	0.889	0.878	0.918	0.800	1.000	Download

Download datasets

Positive dataset

Negative dataset