Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
| Uniprot primary ID | P34972 |
| PDB ID | 2KI9 |
| DrugBank ID | DB00470 DB00486 |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 57 |
| PharmGKB ID | PA26682 |
| KEGG ID | hsa:1269 |
| BioCyc | |
| Entrez Gene (Gene ID) | 1269 |
| DIP | |
| STRING | 9606ENSP00000363596 |
| MINT | |
| IntAct | P34972 |
| DMDM | 461697 |
| BREDNA | |
| Rectome | R-HSA-418594 R-HSA-373076 |
| SignaLink | |
| BindingDB | P34972 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.743 | 0.857 | 0.765 | 0.676 | 0.856 | 0.760 | 0.865 | 0.774 | 0.710 | 0.840 | Download |
| MACCS fingerprints | 0.744 | 0.824 | 0.742 | 0.743 | 0.741 | 0.758 | 0.836 | 0.756 | 0.752 | 0.761 | Download |
| Daylight fingerprints | 0.671 | 0.681 | 0.663 | 0.684 | 0.642 | 0.659 | 0.666 | 0.645 | 0.679 | 0.611 | Download |
| ECFP2 fingerprints | 0.836 | 0.926 | 0.842 | 0.805 | 0.879 | 0.854 | 0.936 | 0.857 | 0.827 | 0.887 | Download |
| ECFP4 fingerprints | 0.879 | 0.949 | 0.884 | 0.835 | 0.934 | 0.884 | 0.958 | 0.887 | 0.851 | 0.924 | Download |
| ECFP6 fingerprints | 0.864 | 0.942 | 0.872 | 0.809 | 0.936 | 0.878 | 0.954 | 0.883 | 0.838 | 0.929 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
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