Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM.
| Uniprot primary ID | P35228 |
| PDB ID | 1NSI 3EJ8 4NOS 3E7G 2NSI 3HR4 2LL6 4CX7 |
| DrugBank ID | DB00997 DB01110 DB01234 DB00125 DB00155 DB08814 |
| BioGrid ID | 110906 |
| GuidetoPHARMACOLOGY ID | 1250 |
| PharmGKB ID | PA164724093 |
| KEGG ID | hsa:4843 |
| BioCyc | MetaCyc:HS00205-MONOMER |
| Entrez Gene (Gene ID) | 4843 |
| DIP | DIP-59359N |
| STRING | 9606ENSP00000327251 |
| MINT | |
| IntAct | P35228 |
| DMDM | 1352513 |
| BREDNA | 1141339 |
| Rectome | R-HSA-1222556 R-HSA-392154 |
| SignaLink | P35228 |
| BindingDB | P35228 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.764 | 0.848 | 0.764 | 0.759 | 0.770 | 0.826 | 0.891 | 0.821 | 0.836 | 0.805 | Download |
| MACCS fingerprints | 0.720 | 0.742 | 0.698 | 0.771 | 0.623 | 0.740 | 0.769 | 0.722 | 0.780 | 0.662 | Download |
| Daylight fingerprints | 0.666 | 0.678 | 0.670 | 0.654 | 0.686 | 0.638 | 0.681 | 0.655 | 0.597 | 0.714 | Download |
| ECFP2 fingerprints | 0.798 | 0.863 | 0.797 | 0.797 | 0.797 | 0.849 | 0.904 | 0.843 | 0.868 | 0.818 | Download |
| ECFP4 fingerprints | 0.820 | 0.887 | 0.823 | 0.802 | 0.844 | 0.850 | 0.912 | 0.850 | 0.836 | 0.864 | Download |
| ECFP6 fingerprints | 0.813 | 0.889 | 0.819 | 0.778 | 0.862 | 0.861 | 0.914 | 0.863 | 0.836 | 0.890 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
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