Details-Calcnet-AlzheimerNet

Target name

P35610: Sterol O-acyltransferase 1

Protein function

Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.

Database links

Uniprot primary ID	P35610
PDB ID
DrugBank ID	DB01094 DB00973
BioGrid ID	112529
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA36015
KEGG ID	hsa:6646
BioCyc
Entrez Gene (Gene ID)	6646
DIP
STRING	9606ENSP00000356591
MINT
IntAct	P35610
DMDM	33302623
BREDNA	23126
Rectome
SignaLink
BindingDB	P35610

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.695	0.768	0.735	0.582	0.899	0.777	0.812	0.777	0.667	0.930	Download
MACCS fingerprints	0.740	0.789	0.735	0.728	0.742	0.825	0.813	0.806	0.783	0.837	Download
Daylight fingerprints	0.656	0.688	0.684	0.582	0.793	0.724	0.735	0.718	0.633	0.837	Download
ECFP2 fingerprints	0.792	0.793	0.805	0.714	0.904	0.844	0.902	0.835	0.767	0.930	Download
ECFP4 fingerprints	0.804	0.832	0.815	0.732	0.904	0.844	0.901	0.835	0.767	0.930	Download
ECFP6 fingerprints	0.797	0.828	0.810	0.718	0.909	0.822	0.890	0.816	0.733	0.930	Download

Download datasets

Positive dataset

Negative dataset