Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.
| Uniprot primary ID | P35869 |
| PDB ID | |
| DrugBank ID | DB01076 DB00499 DB01097 DB01404 DB00393 DB00379 |
| BioGrid ID | 106699 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA24641 |
| KEGG ID | hsa:196 |
| BioCyc | |
| Entrez Gene (Gene ID) | 196 |
| DIP | DIP-946N |
| STRING | 9606ENSP00000242057 |
| MINT | MINT-6597538 |
| IntAct | P35869 |
| DMDM | 3041653 |
| BREDNA | |
| Rectome | |
| SignaLink | P35869 |
| BindingDB | P35869 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.717 | 0.781 | 0.724 | 0.693 | 0.756 | 0.691 | 0.759 | 0.699 | 0.651 | 0.750 | Download |
| MACCS fingerprints | 0.771 | 0.809 | 0.764 | 0.789 | 0.738 | 0.759 | 0.783 | 0.747 | 0.767 | 0.725 | Download |
| Daylight fingerprints | 0.638 | 0.684 | 0.670 | 0.578 | 0.762 | 0.615 | 0.644 | 0.639 | 0.558 | 0.725 | Download |
| ECFP2 fingerprints | 0.734 | 0.755 | 0.715 | 0.783 | 0.646 | 0.778 | 0.821 | 0.759 | 0.814 | 0.700 | Download |
| ECFP4 fingerprints | 0.800 | 0.813 | 0.776 | 0.892 | 0.659 | 0.796 | 0.816 | 0.771 | 0.860 | 0.675 | Download |
| ECFP6 fingerprints | 0.799 | 0.826 | 0.779 | 0.873 | 0.683 | 0.761 | 0.817 | 0.735 | 0.814 | 0.650 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
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