Details-Calcnet-AlzheimerNet

Target name

P36544: Neuronal acetylcholine receptor subunit alpha-7

Protein function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Database links

Uniprot primary ID	P36544
PDB ID	2MAW
DrugBank ID	DB00237 DB00898 DB01351 DB00514 DB01352 DB01353 DB00674 DB00312 DB00599 DB01354 DB01355 DB00306 DB00849 DB00241 DB01174 DB00418 DB00794 DB00184 DB09028 DB01273
BioGrid ID	107561
GuidetoPHARMACOLOGY ID	468
PharmGKB ID	PA114;PA26483
KEGG ID	hsa:1139
BioCyc
Entrez Gene (Gene ID)	89832;1139
DIP
STRING	9606ENSP00000299847
MINT
IntAct	P36544
DMDM	2506127
BREDNA
Rectome	R-HSA-629594
SignaLink	P36544
BindingDB	P36544

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.766	0.846	0.772	0.741	0.804	0.824	0.911	0.822	0.824	0.820	Download
MACCS fingerprints	0.754	0.801	0.730	0.820	0.640	0.741	0.803	0.705	0.825	0.580	Download
Daylight fingerprints	0.735	0.761	0.741	0.715	0.768	0.793	0.837	0.788	0.801	0.774	Download
ECFP2 fingerprints	0.804	0.870	0.804	0.804	0.803	0.860	0.931	0.855	0.882	0.827	Download
ECFP4 fingerprints	0.821	0.899	0.830	0.780	0.880	0.883	0.926	0.885	0.860	0.910	Download
ECFP6 fingerprints	0.813	0.895	0.828	0.744	0.912	0.866	0.925	0.870	0.831	0.910	Download

Download datasets

Positive dataset

Negative dataset