Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).
| Uniprot primary ID | P37231 |
| PDB ID | 3HO0 4O8F 2OM9 1RDT 1ZGY 4CI5 3R8A 3WJ4 3WJ5 1KNU 3PRG 3X1H 2VSR 2Q61 3VN2 3IA6 3AN4 3X1I 3AN3 4L98 3G9E 2VST 4HEE 4F9M 3T03 3V9V 2I4P 3ET0 2I4J 3R5N 3ET3 2HFP 3LMP 2PRG 2VV0 3V9Y 3H0A 1K74 3QT0 4EMA 3V9T 2I4Z 4PRG 3S9S 1I7I 1ZEO 3KMG 3HOD 3B0R 3B0Q 4OJ4 |
| DrugBank ID | DB01050 DB00159 DB01067 DB00328 DB00795 DB00731 DB00966 DB01393 DB01252 DB01132 DB01014 DB00244 DB00412 DB00912 |
| BioGrid ID | 111464 |
| GuidetoPHARMACOLOGY ID | 595 |
| PharmGKB ID | PA281 |
| KEGG ID | hsa:5468 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5468 |
| DIP | DIP-35528N |
| STRING | 9606ENSP00000287820 |
| MINT | |
| IntAct | P37231 |
| DMDM | 13432234 |
| BREDNA | |
| Rectome | R-HSA-1989781 R-HSA-383280 R-HSA-381340 |
| SignaLink | P37231 |
| BindingDB | P37231 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.832 | 0.888 | 0.839 | 0.794 | 0.884 | 0.849 | 0.901 | 0.853 | 0.823 | 0.884 | Download |
| MACCS fingerprints | 0.823 | 0.872 | 0.821 | 0.831 | 0.810 | 0.803 | 0.859 | 0.800 | 0.822 | 0.779 | Download |
| Daylight fingerprints | 0.796 | 0.824 | 0.805 | 0.761 | 0.849 | 0.803 | 0.833 | 0.814 | 0.760 | 0.867 | Download |
| ECFP2 fingerprints | 0.905 | 0.946 | 0.904 | 0.914 | 0.895 | 0.917 | 0.964 | 0.917 | 0.923 | 0.911 | Download |
| ECFP4 fingerprints | 0.899 | 0.946 | 0.901 | 0.883 | 0.919 | 0.905 | 0.964 | 0.907 | 0.892 | 0.921 | Download |
| ECFP6 fingerprints | 0.881 | 0.940 | 0.886 | 0.843 | 0.929 | 0.891 | 0.953 | 0.895 | 0.856 | 0.934 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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