Target name

P37231: Peroxisome proliferator-activated receptor gamma

  Protein function

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

  Database links

Uniprot primary ID P37231
PDB ID 3HO0 4O8F 2OM9 1RDT 1ZGY 4CI5 3R8A 3WJ4 3WJ5 1KNU 3PRG 3X1H 2VSR 2Q61 3VN2 3IA6 3AN4 3X1I 3AN3 4L98 3G9E 2VST 4HEE 4F9M 3T03 3V9V 2I4P 3ET0 2I4J 3R5N 3ET3 2HFP 3LMP 2PRG 2VV0 3V9Y 3H0A 1K74 3QT0 4EMA 3V9T 2I4Z 4PRG 3S9S 1I7I 1ZEO 3KMG 3HOD 3B0R 3B0Q 4OJ4
DrugBank ID DB01050 DB00159 DB01067 DB00328 DB00795 DB00731 DB00966 DB01393 DB01252 DB01132 DB01014 DB00244 DB00412 DB00912
BioGrid ID 111464
PharmGKB ID PA281
KEGG ID hsa:5468
Entrez Gene (Gene ID) 5468
DIP DIP-35528N
STRING 9606ENSP00000287820
IntAct P37231
DMDM 13432234
Rectome R-HSA-1989781 R-HSA-383280 R-HSA-381340
SignaLink P37231
BindingDB P37231

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.832 0.888 0.839 0.794 0.884 0.849 0.901 0.853 0.823 0.884 Download
MACCS fingerprints 0.823 0.872 0.821 0.831 0.810 0.803 0.859 0.800 0.822 0.779 Download
Daylight fingerprints 0.796 0.824 0.805 0.761 0.849 0.803 0.833 0.814 0.760 0.867 Download
ECFP2 fingerprints 0.905 0.946 0.904 0.914 0.895 0.917 0.964 0.917 0.923 0.911 Download
ECFP4 fingerprints 0.899 0.946 0.901 0.883 0.919 0.905 0.964 0.907 0.892 0.921 Download
ECFP6 fingerprints 0.881 0.940 0.886 0.843 0.929 0.891 0.953 0.895 0.856 0.934 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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