Details-Calcnet-AlzheimerNet

Target name

P39900: Macrophage metalloelastase

Protein function

May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3.

Database links

Uniprot primary ID	P39900
PDB ID	2KRJ 1UTT 2MLR 3EHX 3EHY 1UTZ 1Y93 3RTT 3UVC 4H76 2POJ 1JIZ 2W0D 3LJG 1YCM 2HU6 3LK8 2WOA 2OXZ 2OXU 2OXW 2K2G 4EFS 3RTS 3N2U 3F15 3F16 3F17 3F18 2JXY 2MLS 3F1A 2Z2D 3BA0 4GQL 3N2V 2K9C 4GUY 3TSK 4IJO 3F19 2WO8 2WO9 4I03 1OS2 3NX7 4H49 1OS9 3LIL 3LIR 4GR8
DrugBank ID	DB00786 DB00551
BioGrid ID	110464
GuidetoPHARMACOLOGY ID	1636
PharmGKB ID	PA30870
KEGG ID	hsa:4321
BioCyc
Entrez Gene (Gene ID)	4321
DIP
STRING
MINT	MINT-7709562
IntAct	P39900
DMDM	729179
BREDNA
Rectome	R-HSA-1474228 R-HSA-1442490
SignaLink
BindingDB	P39900

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.848	0.890	0.853	0.826	0.879	0.868	0.904	0.866	0.828	0.909	Download
MACCS fingerprints	0.833	0.905	0.834	0.828	0.839	0.848	0.926	0.845	0.818	0.875	Download
Daylight fingerprints	0.790	0.839	0.812	0.708	0.917	0.777	0.836	0.791	0.687	0.909	Download
ECFP2 fingerprints	0.864	0.923	0.867	0.845	0.890	0.907	0.967	0.904	0.889	0.920	Download
ECFP4 fingerprints	0.887	0.945	0.891	0.855	0.928	0.910	0.970	0.909	0.869	0.955	Download
ECFP6 fingerprints	0.882	0.937	0.889	0.828	0.949	0.903	0.962	0.904	0.848	0.966	Download

Download datasets

Positive dataset

Negative dataset