Details-Calcnet-AlzheimerNet

Target name

P41231: P2Y purinoceptor 2

Protein function

Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

Database links

Uniprot primary ID	P41231
PDB ID	1Z8E
DrugBank ID	DB04786
BioGrid ID	111068
GuidetoPHARMACOLOGY ID	324
PharmGKB ID	PA32870
KEGG ID	hsa:5029
BioCyc
Entrez Gene (Gene ID)	5029
DIP
STRING	9606ENSP00000310305
MINT	MINT-1796620
IntAct	P41231
DMDM	311033490
BREDNA
Rectome	R-HSA-416476 R-HSA-417957
SignaLink	P41231
BindingDB	P41231

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.881	0.880	0.880	0.885	0.875	0.879	0.871	0.872	0.927	0.815	Download
MACCS fingerprints	0.901	0.897	0.898	0.926	0.870	0.926	0.919	0.917	0.903	0.936	Download
Daylight fingerprints	0.870	0.871	0.869	0.876	0.861	0.862	0.860	0.853	0.909	0.796	Download
ECFP2 fingerprints	0.902	0.899	0.899	0.927	0.870	0.879	0.871	0.872	0.927	0.815	Download
ECFP4 fingerprints	0.906	0.902	0.903	0.927	0.880	0.879	0.871	0.872	0.927	0.815	Download
ECFP6 fingerprints	0.906	0.907	0.903	0.927	0.880	0.879	0.871	0.872	0.927	0.815	Download

Download datasets

Positive dataset

Negative dataset