Target name

P42574: Caspase-3


  Protein function

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.

  Database links

Uniprot primary ID P42574
PDB ID 2J31 2J30 2J33 2J32 4EHH 4EHK 4EHL 4EHD 4EHF 4EHA 2XYP 4JQZ 4QUB 4EHN 3PCX 4QUG 4QUD 1CP3 4QUJ 4QUH 4QUI 2XYG 4QUL 1RE1 3PD1 3PD0 3KJF 3DEJ 3DEK 3DEH 3DEI 2DKO 2XZT 2CJY 2CJX 4QTY 3H0E 1PAU 2XZD 4PS0 4JQY 3ITN 2CDR 4DCO 3GJS 4DCJ 4QUE 2C2K 4QUA 4DCP 4PRY
DrugBank ID DB01017
BioGrid ID 107286
GuidetoPHARMACOLOGY ID 1619
PharmGKB ID PA26087
KEGG ID hsa:836
BioCyc
Entrez Gene (Gene ID) 836
DIP DIP-268N
STRING 9606ENSP00000311032
MINT MINT-147180
IntAct P42574
DMDM 77416852
BREDNA 342256
Rectome R-HSA-211227 R-HSA-205025 R-HSA-264870 R-HSA-111465 R-HSA-111464 R-HSA-211736 R-HSA-1474228 R-HSA-2028269 R-HSA-111463 R-HSA-351906 R-HSA-111459 R-HSA-418889
SignaLink
BindingDB P42574

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.814 0.853 0.826 0.770 0.881 0.822 0.856 0.836 0.792 0.877 Download
MACCS fingerprints 0.752 0.803 0.763 0.731 0.795 0.746 0.807 0.767 0.719 0.811 Download
Daylight fingerprints 0.757 0.771 0.759 0.761 0.757 0.763 0.791 0.774 0.765 0.782 Download
ECFP2 fingerprints 0.776 0.834 0.798 0.710 0.883 0.789 0.842 0.815 0.729 0.893 Download
ECFP4 fingerprints 0.803 0.865 0.824 0.727 0.918 0.820 0.872 0.841 0.760 0.914 Download
ECFP6 fingerprints 0.808 0.862 0.829 0.728 0.927 0.814 0.869 0.838 0.742 0.926 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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