Details-Calcnet-AlzheimerNet

Target name

P43681: Neuronal acetylcholine receptor subunit alpha-4

Protein function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.

Database links

Uniprot primary ID	P43681
PDB ID	2LLY 2GVT
DrugBank ID	DB00237 DB00898 DB01351 DB00514 DB01352 DB01353 DB00674 DB00312 DB00599 DB01354 DB01355 DB00306 DB00849 DB00241 DB01174 DB00418 DB00794 DB00184 DB09028 DB01273
BioGrid ID	107559
GuidetoPHARMACOLOGY ID	465
PharmGKB ID	PA26490
KEGG ID	hsa:1137
BioCyc
Entrez Gene (Gene ID)	1137
DIP
STRING	9606ENSP00000359285
MINT	MINT-3015931
IntAct	P43681
DMDM	1351848
BREDNA
Rectome	R-HSA-629587 R-HSA-629597 R-HSA-629594
SignaLink
BindingDB	P43681

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.801	0.860	0.801	0.800	0.803	0.814	0.861	0.808	0.829	0.787	Download
MACCS fingerprints	0.791	0.853	0.782	0.820	0.744	0.788	0.859	0.783	0.844	0.726	Download
Daylight fingerprints	0.700	0.716	0.708	0.677	0.739	0.732	0.740	0.736	0.710	0.763	Download
ECFP2 fingerprints	0.833	0.904	0.837	0.805	0.870	0.836	0.919	0.836	0.820	0.853	Download
ECFP4 fingerprints	0.863	0.917	0.868	0.828	0.910	0.883	0.925	0.886	0.853	0.919	Download
ECFP6 fingerprints	0.854	0.910	0.861	0.808	0.915	0.880	0.925	0.883	0.848	0.919	Download

Download datasets

Positive dataset

Negative dataset