Target name

P49768: Presenilin-1


  Protein function

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

  Database links

Uniprot primary ID P49768
PDB ID 2KR6
DrugBank ID
BioGrid ID 111642
GuidetoPHARMACOLOGY ID 2402
PharmGKB ID PA33855
KEGG ID hsa:5663
BioCyc
Entrez Gene (Gene ID) 5663
DIP DIP-1134N
STRING 9606ENSP00000326366
MINT MINT-88325
IntAct P49768
DMDM 1709856
BREDNA
Rectome R-HSA-1474228
SignaLink P49768
BindingDB P49768

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.832 0.865 0.827 0.848 0.805 0.944 0.945 0.949 0.895 1.000 Download
MACCS fingerprints 0.827 0.832 0.801 0.937 0.662 0.857 0.957 0.846 0.947 0.750 Download
Daylight fingerprints 0.844 0.859 0.853 0.785 0.922 0.914 0.921 0.923 0.842 1.000 Download
ECFP2 fingerprints 0.752 0.864 0.737 0.785 0.688 0.919 0.954 0.923 0.895 0.950 Download
ECFP4 fingerprints 0.776 0.863 0.782 0.747 0.818 0.919 0.942 0.923 0.895 0.950 Download
ECFP6 fingerprints 0.808 0.873 0.814 0.772 0.857 0.919 0.939 0.923 0.895 0.950 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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