Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
| Uniprot primary ID | P49810 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | 111643 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA33856 |
| KEGG ID | hsa:5664 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5664 |
| DIP | |
| STRING | 9606ENSP00000355747 |
| MINT | MINT-95242 |
| IntAct | P49810 |
| DMDM | 1709858 |
| BREDNA | |
| Rectome | R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096 |
| SignaLink | P49810 |
| BindingDB | P49810 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.886 | 0.916 | 0.884 | 0.891 | 0.876 | 0.944 | 0.968 | 0.941 | 0.967 | 0.914 | Download |
| MACCS fingerprints | 0.775 | 0.878 | 0.786 | 0.728 | 0.845 | 0.891 | 0.931 | 0.890 | 0.869 | 0.912 | Download |
| Daylight fingerprints | 0.823 | 0.879 | 0.837 | 0.749 | 0.927 | 0.900 | 0.913 | 0.899 | 0.885 | 0.914 | Download |
| ECFP2 fingerprints | 0.902 | 0.945 | 0.901 | 0.908 | 0.893 | 0.959 | 0.970 | 0.958 | 0.967 | 0.948 | Download |
| ECFP4 fingerprints | 0.929 | 0.946 | 0.928 | 0.925 | 0.932 | 0.951 | 0.963 | 0.950 | 0.951 | 0.948 | Download |
| ECFP6 fingerprints | 0.905 | 0.945 | 0.907 | 0.874 | 0.940 | 0.951 | 0.969 | 0.950 | 0.951 | 0.948 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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