Target name

P49862: Kallikrein-7


  Protein function

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.

  Database links

Uniprot primary ID P49862
PDB ID 2QXJ 2QXI 2QXH 2QXG 3BSQ
DrugBank ID
BioGrid ID 111631
GuidetoPHARMACOLOGY ID
PharmGKB ID PA30157
KEGG ID hsa:5650
BioCyc
Entrez Gene (Gene ID) 5650
DIP
STRING 9606ENSP00000375683
MINT
IntAct P49862
DMDM 1710878
BREDNA 3421117
Rectome R-HSA-1474228
SignaLink
BindingDB P49862

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.378 0.558 0.744 0.375 0.841 0.261 0.676 0.750 0.300 0.828 Download
MACCS fingerprints 0.182 0.416 0.633 0.196 0.748 0.240 0.602 0.721 0.300 0.793 Download
Daylight fingerprints 0.348 0.609 0.722 0.357 0.818 0.250 0.571 0.735 0.300 0.810 Download
ECFP2 fingerprints 0.000 0.455 0.778 0.000 0.981 0.000 0.579 0.853 0.000 1.000 Download
ECFP4 fingerprints 0.000 0.407 0.730 0.000 0.921 0.143 0.578 0.824 0.100 0.948 Download
ECFP6 fingerprints 0.146 0.450 0.741 0.107 0.907 0.375 0.578 0.853 0.300 0.948 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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