Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
| Uniprot primary ID | P50052 |
| PDB ID | |
| DrugBank ID | DB01349 |
| BioGrid ID | 106692 |
| GuidetoPHARMACOLOGY ID | 35 |
| PharmGKB ID | PA44 |
| KEGG ID | hsa:186 |
| BioCyc | |
| Entrez Gene (Gene ID) | 186 |
| DIP | |
| STRING | 9606ENSP00000360973 |
| MINT | |
| IntAct | P50052 |
| DMDM | 1703214 |
| BREDNA | |
| Rectome | R-HSA-418594 R-HSA-375276 |
| SignaLink | |
| BindingDB | P50052 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.900 | 0.924 | 0.908 | 0.822 | 0.994 | 0.938 | 0.951 | 0.943 | 0.893 | 0.989 | Download |
| MACCS fingerprints | 0.827 | 0.906 | 0.837 | 0.779 | 0.894 | 0.825 | 0.896 | 0.840 | 0.786 | 0.890 | Download |
| Daylight fingerprints | 0.885 | 0.894 | 0.888 | 0.860 | 0.917 | 0.886 | 0.921 | 0.891 | 0.881 | 0.901 | Download |
| ECFP2 fingerprints | 0.951 | 0.987 | 0.953 | 0.914 | 0.991 | 0.931 | 0.987 | 0.937 | 0.881 | 0.989 | Download |
| ECFP4 fingerprints | 0.954 | 0.986 | 0.956 | 0.914 | 0.997 | 0.937 | 0.974 | 0.943 | 0.881 | 1.000 | Download |
| ECFP6 fingerprints | 0.946 | 0.969 | 0.948 | 0.897 | 1.000 | 0.923 | 0.952 | 0.931 | 0.857 | 1.000 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
All rights reserved.
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E-mail: biomed@csu.edu.cn
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