This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:
| Uniprot primary ID | P50406 |
| PDB ID | |
| DrugBank ID | DB00458 DB01142 DB00477 DB00334 DB06216 DB04946 DB01224 DB00321 DB01049 DB00408 DB00363 DB00246 DB06148 DB00543 DB00540 DB06144 DB01238 |
| BioGrid ID | 109594 |
| GuidetoPHARMACOLOGY ID | 11 |
| PharmGKB ID | PA29560 |
| KEGG ID | hsa:3362 |
| BioCyc | |
| Entrez Gene (Gene ID) | 3362 |
| DIP | |
| STRING | 9606ENSP00000289753 |
| MINT | MINT-7214563 |
| IntAct | P50406 |
| DMDM | 1703010 |
| BREDNA | |
| Rectome | R-HSA-390666 R-HSA-418555 |
| SignaLink | |
| BindingDB | P50406 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.798 | 0.870 | 0.797 | 0.796 | 0.798 | 0.803 | 0.881 | 0.801 | 0.804 | 0.799 | Download |
| MACCS fingerprints | 0.766 | 0.825 | 0.754 | 0.804 | 0.703 | 0.780 | 0.843 | 0.768 | 0.819 | 0.717 | Download |
| Daylight fingerprints | 0.761 | 0.829 | 0.777 | 0.706 | 0.848 | 0.762 | 0.838 | 0.778 | 0.708 | 0.849 | Download |
| ECFP2 fingerprints | 0.852 | 0.929 | 0.848 | 0.873 | 0.823 | 0.867 | 0.941 | 0.863 | 0.890 | 0.834 | Download |
| ECFP4 fingerprints | 0.871 | 0.942 | 0.872 | 0.858 | 0.886 | 0.883 | 0.952 | 0.884 | 0.870 | 0.898 | Download |
| ECFP6 fingerprints | 0.856 | 0.935 | 0.862 | 0.819 | 0.904 | 0.875 | 0.948 | 0.879 | 0.838 | 0.921 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
All rights reserved.
The recommended browsers: Safari, Firefox, Chrome,IE(Ver.>8).
E-mail: biomed@csu.edu.cn
 |
 |
 |
 |
 |
 |