Details-Calcnet-AlzheimerNet

Target name

P51677: C-C chemokine receptor type 3

Protein function

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Database links

Uniprot primary ID	P51677
PDB ID
DrugBank ID
BioGrid ID	107637
GuidetoPHARMACOLOGY ID	60
PharmGKB ID	PA26168
KEGG ID
BioCyc
Entrez Gene (Gene ID)	1232
DIP	DIP-5846N
STRING	9606ENSP00000441600
MINT	MINT-105239
IntAct	P51677
DMDM	1705892
BREDNA
Rectome	R-HSA-418594 R-HSA-380108
SignaLink
BindingDB	P51677

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.879	0.925	0.880	0.876	0.884	0.907	0.957	0.904	0.900	0.908	Download
MACCS fingerprints	0.826	0.903	0.823	0.847	0.798	0.846	0.931	0.846	0.866	0.827	Download
Daylight fingerprints	0.860	0.886	0.861	0.860	0.862	0.886	0.913	0.885	0.867	0.904	Download
ECFP2 fingerprints	0.911	0.961	0.913	0.897	0.929	0.932	0.982	0.931	0.911	0.952	Download
ECFP4 fingerprints	0.934	0.970	0.936	0.909	0.963	0.940	0.988	0.939	0.926	0.952	Download
ECFP6 fingerprints	0.933	0.967	0.936	0.897	0.974	0.945	0.984	0.944	0.915	0.976	Download

Download datasets

Positive dataset

Negative dataset