Details-Calcnet-AlzheimerNet

Target name

P51681: C-C chemokine receptor type 5

Protein function

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

Database links

Uniprot primary ID	P51681
PDB ID	1NE0 4MBS 1ND8 1OPN 2RLL 2RRS 2L87 1OPT 2MZX 1OPW
DrugBank ID	DB04835
BioGrid ID	107639
GuidetoPHARMACOLOGY ID	62
PharmGKB ID	PA26170
KEGG ID	hsa:1234
BioCyc
Entrez Gene (Gene ID)	1234
DIP	DIP-5866N
STRING	9606ENSP00000292303
MINT	MINT-103024
IntAct	P51681
DMDM	1705896
BREDNA
Rectome	R-HSA-173107 R-HSA-380108 R-HSA-418594
SignaLink	P51681
BindingDB	P51681

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.892	0.927	0.890	0.909	0.872	0.914	0.935	0.908	0.919	0.896	Download
MACCS fingerprints	0.861	0.945	0.847	0.947	0.747	0.877	0.949	0.860	0.949	0.761	Download
Daylight fingerprints	0.883	0.898	0.886	0.867	0.905	0.886	0.896	0.884	0.862	0.908	Download
ECFP2 fingerprints	0.939	0.970	0.940	0.930	0.949	0.957	0.978	0.955	0.949	0.962	Download
ECFP4 fingerprints	0.943	0.964	0.945	0.917	0.973	0.953	0.976	0.952	0.930	0.976	Download
ECFP6 fingerprints	0.939	0.962	0.941	0.904	0.978	0.950	0.976	0.950	0.917	0.986	Download

Download datasets

Positive dataset

Negative dataset