Nuclear receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Exhibits a ligand-dependent transcriptional activation activity (PubMed:
| Uniprot primary ID | P55055 |
| PDB ID | 1PQ9 3L0E 4RAK 1PQC 4NQA 1P8D 1UPV 4DK8 3KFC 1PQ6 4DK7 1UPW |
| DrugBank ID | |
| BioGrid ID | 113222 |
| GuidetoPHARMACOLOGY ID | 601 |
| PharmGKB ID | PA31750 |
| KEGG ID | hsa:7376 |
| BioCyc | |
| Entrez Gene (Gene ID) | 7376 |
| DIP | DIP-53004N |
| STRING | 9606ENSP00000253727 |
| MINT | MINT-1444220 |
| IntAct | P55055 |
| DMDM | 296439251 |
| BREDNA | |
| Rectome | R-HSA-383280 |
| SignaLink | P55055 |
| BindingDB | P55055 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.917 | 0.916 | 0.917 | 0.904 | 0.931 | 0.938 | 0.955 | 0.946 | 1.000 | 0.909 | Download |
| MACCS fingerprints | 0.918 | 0.911 | 0.916 | 0.918 | 0.914 | 0.968 | 0.973 | 0.972 | 1.000 | 0.952 | Download |
| Daylight fingerprints | 0.878 | 0.895 | 0.883 | 0.836 | 0.931 | 0.938 | 0.955 | 0.946 | 1.000 | 0.909 | Download |
| ECFP2 fingerprints | 0.897 | 0.908 | 0.897 | 0.890 | 0.903 | 0.938 | 0.952 | 0.946 | 1.000 | 0.909 | Download |
| ECFP4 fingerprints | 0.909 | 0.919 | 0.910 | 0.890 | 0.931 | 0.938 | 0.955 | 0.946 | 1.000 | 0.909 | Download |
| ECFP6 fingerprints | 0.917 | 0.921 | 0.917 | 0.904 | 0.931 | 0.938 | 0.955 | 0.946 | 1.000 | 0.909 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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