Details-Calcnet-AlzheimerNet

Target name

P55210: Caspase-7

Protein function

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.

Database links

Uniprot primary ID	P55210
PDB ID	1I51 2QLJ 1KMC 2QLF 2QLB 1SHL 3IBC 3H1P 3IBF 4FDL 4JR1 1SHJ 1F1J 1I4O 3R5K 1MIA 1GQF 4JR2 4FEA 1K86 4JJ8 3EDR 4HQR 1K88 4HQ0 2QL9 4LSZ 2QL7 2QL5 4JB8
DrugBank ID
BioGrid ID	107290
GuidetoPHARMACOLOGY ID	1623
PharmGKB ID	PA26091
KEGG ID	hsa:840
BioCyc
Entrez Gene (Gene ID)	840
DIP	DIP-29973N
STRING	9606ENSP00000358327
MINT	MINT-147084
IntAct	P55210
DMDM	1730092
BREDNA	342260
Rectome	R-HSA-111465 R-HSA-111464 R-HSA-111459 R-HSA-111463 R-HSA-264870
SignaLink
BindingDB	P55210

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.848	0.891	0.858	0.828	0.886	0.879	0.890	0.875	0.884	0.866	Download
MACCS fingerprints	0.772	0.873	0.788	0.753	0.820	0.852	0.882	0.845	0.872	0.817	Download
Daylight fingerprints	0.764	0.814	0.800	0.678	0.911	0.768	0.789	0.792	0.674	0.915	Download
ECFP2 fingerprints	0.867	0.917	0.870	0.884	0.857	0.905	0.953	0.899	0.942	0.854	Download
ECFP4 fingerprints	0.879	0.926	0.884	0.888	0.880	0.898	0.934	0.893	0.919	0.866	Download
ECFP6 fingerprints	0.876	0.915	0.882	0.872	0.891	0.895	0.935	0.893	0.895	0.890	Download

Download datasets

Positive dataset

Negative dataset