Details-Calcnet-AlzheimerNet

Target name

P55211: Caspase-9

Protein function

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).

Database links

Uniprot primary ID	P55211
PDB ID	3YGS 1JXQ 3V3K 2AR9 3D9T 1NW9 4RHW
DrugBank ID
BioGrid ID	107292
GuidetoPHARMACOLOGY ID	1625
PharmGKB ID	PA26094
KEGG ID	hsa:842
BioCyc
Entrez Gene (Gene ID)	842
DIP	DIP-27625N
STRING	9606ENSP00000330237
MINT	MINT-89165
IntAct	P55211
DMDM	28558771
BREDNA	342262
Rectome	R-HSA-111464 R-HSA-168638 R-HSA-418889 R-HSA-5674400 R-HSA-111463 R-HSA-198323 R-HSA-111458 R-HSA-111459
SignaLink
BindingDB	P55211

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.569	0.644	0.603	0.589	0.614	0.495	0.627	0.564	0.455	0.661	Download
MACCS fingerprints	0.568	0.623	0.605	0.585	0.622	0.531	0.570	0.547	0.545	0.548	Download
Daylight fingerprints	0.552	0.620	0.599	0.556	0.633	0.574	0.585	0.581	0.600	0.565	Download
ECFP2 fingerprints	0.395	0.549	0.494	0.372	0.591	0.594	0.696	0.650	0.545	0.742	Download
ECFP4 fingerprints	0.605	0.687	0.624	0.647	0.606	0.712	0.730	0.709	0.764	0.661	Download
ECFP6 fingerprints	0.637	0.700	0.655	0.681	0.633	0.701	0.716	0.701	0.745	0.661	Download

Download datasets

Positive dataset

Negative dataset