Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
| Uniprot primary ID | P55212 |
| PDB ID | 4EJF 3K7E 4N6G 3S70 3V6M 3V6L 3OD5 3NKF 3S8E 4N5D 4HVA 3P45 2WDP 1MI9 4FXO 4N7M 4N7J 3QNW 4NBK 4NBL 4NBN 3P4U 4IYR 3NR2 |
| DrugBank ID | |
| BioGrid ID | 107289 |
| GuidetoPHARMACOLOGY ID | 1622 |
| PharmGKB ID | PA26090 |
| KEGG ID | hsa:839 |
| BioCyc | |
| Entrez Gene (Gene ID) | 839 |
| DIP | DIP-44649N |
| STRING | 9606ENSP00000265164 |
| MINT | MINT-1374245 |
| IntAct | P55212 |
| DMDM | 26006981 |
| BREDNA | 342259 |
| Rectome | R-HSA-111465 R-HSA-352238 R-HSA-264870 |
| SignaLink | |
| BindingDB | P55212 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.582 | 0.622 | 0.608 | 0.646 | 0.580 | 0.723 | 0.795 | 0.735 | 0.895 | 0.633 | Download |
| MACCS fingerprints | 0.592 | 0.625 | 0.624 | 0.646 | 0.607 | 0.682 | 0.802 | 0.714 | 0.789 | 0.667 | Download |
| Daylight fingerprints | 0.543 | 0.584 | 0.567 | 0.610 | 0.536 | 0.625 | 0.654 | 0.633 | 0.789 | 0.533 | Download |
| ECFP2 fingerprints | 0.317 | 0.504 | 0.490 | 0.280 | 0.643 | 0.595 | 0.790 | 0.694 | 0.579 | 0.767 | Download |
| ECFP4 fingerprints | 0.533 | 0.610 | 0.593 | 0.549 | 0.625 | 0.773 | 0.842 | 0.796 | 0.895 | 0.733 | Download |
| ECFP6 fingerprints | 0.579 | 0.643 | 0.603 | 0.646 | 0.571 | 0.756 | 0.856 | 0.776 | 0.895 | 0.700 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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