Details-Calcnet-AlzheimerNet

Target name

P56817: Beta-secretase 1

Protein function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

Database links

Uniprot primary ID	P56817
PDB ID	4B1E 4B1D 2QK5 2B8L 4J1K 3QI1 3WB4 1YM4 4B1C 4R93 1YM2 4J1I 4J1H 4FSE 4R5N 4J1E 4DJX 3DUY 3LNK 2B8V 4FSL 2VJ9 1M4H 2VKM 4B0Q 2VJ6 2VJ7 3TPP 4X2L 3TPR 4FM8 3DV1 3WB5 3OOZ 3INE 4ZSM 3QBH 3UQX 4J0V 3MSL 4GID 4J0Z 3UQR 3UQP 3UQW 3VV8 4WTU 3UQU 4J0T 4WY1 3DV5
DrugBank ID
BioGrid ID	117154
GuidetoPHARMACOLOGY ID	2330
PharmGKB ID	PA25232
KEGG ID
BioCyc	MetaCyc:ENSG00000160610-MONOMER
Entrez Gene (Gene ID)	23621
DIP	DIP-41388N
STRING	9606ENSP00000318585
MINT	MINT-242532
IntAct	P56817
DMDM	296434407
BREDNA	342346
Rectome
SignaLink
BindingDB	P56817

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.844	0.862	0.861	0.751	0.971	0.873	0.887	0.879	0.788	0.980	Download
MACCS fingerprints	0.810	0.886	0.824	0.752	0.895	0.852	0.925	0.862	0.783	0.943	Download
Daylight fingerprints	0.809	0.822	0.816	0.776	0.857	0.815	0.818	0.809	0.802	0.816	Download
ECFP2 fingerprints	0.863	0.942	0.875	0.790	0.960	0.883	0.953	0.885	0.823	0.953	Download
ECFP4 fingerprints	0.895	0.943	0.902	0.840	0.964	0.914	0.950	0.913	0.880	0.949	Download
ECFP6 fingerprints	0.902	0.942	0.908	0.847	0.968	0.919	0.950	0.918	0.880	0.961	Download

Download datasets

Positive dataset

Negative dataset