Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
| Uniprot primary ID | Q03181 |
| PDB ID | 2XYX 2XYW 3PEQ 2XYJ 2B50 2J14 2Q5G 2BAW 2ZNP 2ZNQ 1GWX 3ET2 3GWX 3GZ9 3TKM 3SP9 3DY6 3D5F 1Y0S 2GWX 2ENV 2AWH 3OZ0 |
| DrugBank ID | DB00159 DB01393 DB00605 DB00374 |
| BioGrid ID | 111463 |
| GuidetoPHARMACOLOGY ID | 594 |
| PharmGKB ID | PA33557 |
| KEGG ID | hsa:5467 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5467 |
| DIP | |
| STRING | 9606ENSP00000310928 |
| MINT | MINT-1200178 |
| IntAct | Q03181 |
| DMDM | 417522 |
| BREDNA | |
| Rectome | R-HSA-204174 R-HSA-383280 R-HSA-200425 R-HSA-5362517 |
| SignaLink | Q03181 |
| BindingDB | Q03181 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.861 | 0.901 | 0.867 | 0.830 | 0.903 | 0.872 | 0.931 | 0.884 | 0.844 | 0.920 | Download |
| MACCS fingerprints | 0.830 | 0.897 | 0.829 | 0.840 | 0.817 | 0.827 | 0.896 | 0.833 | 0.839 | 0.828 | Download |
| Daylight fingerprints | 0.811 | 0.848 | 0.823 | 0.763 | 0.882 | 0.803 | 0.860 | 0.827 | 0.757 | 0.888 | Download |
| ECFP2 fingerprints | 0.903 | 0.966 | 0.902 | 0.918 | 0.886 | 0.908 | 0.966 | 0.912 | 0.931 | 0.896 | Download |
| ECFP4 fingerprints | 0.930 | 0.965 | 0.930 | 0.930 | 0.929 | 0.920 | 0.964 | 0.925 | 0.922 | 0.928 | Download |
| ECFP6 fingerprints | 0.920 | 0.967 | 0.922 | 0.905 | 0.938 | 0.916 | 0.962 | 0.923 | 0.899 | 0.944 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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