NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity).
| Uniprot primary ID | Q05586 |
| PDB ID | 2HQW 2NR1 3BYA |
| DrugBank ID | DB04896 DB00996 DB01043 DB01174 DB00312 DB06151 DB00659 DB00418 DB01173 DB00454 DB08954 DB00289 DB06738 |
| BioGrid ID | 109159 |
| GuidetoPHARMACOLOGY ID | 455 |
| PharmGKB ID | PA28978 |
| KEGG ID | hsa:2902 |
| BioCyc | |
| Entrez Gene (Gene ID) | 2902 |
| DIP | |
| STRING | 9606ENSP00000360608 |
| MINT | MINT-1900224 |
| IntAct | Q05586 |
| DMDM | 548377 |
| BREDNA | |
| Rectome | R-HSA-442729 R-HSA-5673001 R-HSA-3928662 R-HSA-438066 R-HSA-442982 |
| SignaLink | Q05586 |
| BindingDB | Q05586 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.770 | 0.864 | 0.775 | 0.753 | 0.797 | 0.889 | 0.932 | 0.876 | 0.889 | 0.860 | Download |
| MACCS fingerprints | 0.602 | 0.719 | 0.644 | 0.542 | 0.745 | 0.852 | 0.877 | 0.823 | 0.860 | 0.769 | Download |
| Daylight fingerprints | 0.656 | 0.690 | 0.671 | 0.624 | 0.719 | 0.807 | 0.773 | 0.784 | 0.815 | 0.744 | Download |
| ECFP2 fingerprints | 0.768 | 0.867 | 0.772 | 0.753 | 0.792 | 0.879 | 0.946 | 0.866 | 0.870 | 0.860 | Download |
| ECFP4 fingerprints | 0.855 | 0.923 | 0.855 | 0.851 | 0.859 | 0.927 | 0.963 | 0.918 | 0.944 | 0.884 | Download |
| ECFP6 fingerprints | 0.874 | 0.934 | 0.878 | 0.840 | 0.917 | 0.954 | 0.966 | 0.948 | 0.963 | 0.930 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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