Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
| Uniprot primary ID | Q07869 |
| PDB ID | 3FEI 3KDT 3KDU 1I7G 3ET1 3G8I 4CI4 2NPA 3VI8 2REW 2ZNN 1K7L 3SP6 1KKQ 4BCR 2P54 |
| DrugBank ID | DB00636 DB01039 DB00328 DB01393 DB01241 |
| BioGrid ID | 111461 |
| GuidetoPHARMACOLOGY ID | 593 |
| PharmGKB ID | PA280 |
| KEGG ID | hsa:5465 |
| BioCyc | |
| Entrez Gene (Gene ID) | 5465 |
| DIP | DIP-241N |
| STRING | 9606ENSP00000262735 |
| MINT | MINT-232229 |
| IntAct | Q07869 |
| DMDM | 3041727 |
| BREDNA | |
| Rectome | R-HSA-1989781 R-HSA-383280 R-HSA-1368082 R-HSA-400206 R-HSA-381340 R-HSA-2426168 R-HSA-2151201 R-HSA-2032785 R-HSA-400253 R-HSA-1368108 |
| SignaLink | Q07869 |
| BindingDB | Q07869 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.864 | 0.897 | 0.869 | 0.834 | 0.903 | 0.873 | 0.900 | 0.871 | 0.847 | 0.898 | Download |
| MACCS fingerprints | 0.861 | 0.897 | 0.854 | 0.901 | 0.808 | 0.881 | 0.908 | 0.873 | 0.913 | 0.829 | Download |
| Daylight fingerprints | 0.841 | 0.872 | 0.852 | 0.786 | 0.917 | 0.853 | 0.882 | 0.855 | 0.802 | 0.914 | Download |
| ECFP2 fingerprints | 0.886 | 0.941 | 0.883 | 0.908 | 0.858 | 0.907 | 0.952 | 0.900 | 0.926 | 0.872 | Download |
| ECFP4 fingerprints | 0.903 | 0.940 | 0.903 | 0.904 | 0.901 | 0.917 | 0.952 | 0.913 | 0.921 | 0.903 | Download |
| ECFP6 fingerprints | 0.894 | 0.940 | 0.896 | 0.877 | 0.914 | 0.912 | 0.951 | 0.909 | 0.907 | 0.911 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
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