NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
| Uniprot primary ID | Q13224 |
| PDB ID | 1S2S 2IPV 1S11 |
| DrugBank ID | DB04896 DB00996 DB00502 DB00949 DB01174 DB00312 DB06151 DB00659 DB00418 DB01043 DB00454 DB08954 DB00289 DB06738 |
| BioGrid ID | 109161 |
| GuidetoPHARMACOLOGY ID | 457 |
| PharmGKB ID | PA28980 |
| KEGG ID | hsa:2904 |
| BioCyc | |
| Entrez Gene (Gene ID) | 2904 |
| DIP | DIP-41002N |
| STRING | 9606ENSP00000279593 |
| MINT | MINT-127466 |
| IntAct | Q13224 |
| DMDM | 14548162 |
| BREDNA | |
| Rectome | R-HSA-442729 R-HSA-5673001 R-HSA-3928662 R-HSA-438066 R-HSA-442982 |
| SignaLink | Q13224 |
| BindingDB | Q13224 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.816 | 0.908 | 0.814 | 0.816 | 0.812 | 0.869 | 0.938 | 0.852 | 0.930 | 0.765 | Download |
| MACCS fingerprints | 0.756 | 0.815 | 0.755 | 0.756 | 0.755 | 0.838 | 0.912 | 0.822 | 0.803 | 0.848 | Download |
| Daylight fingerprints | 0.655 | 0.673 | 0.672 | 0.618 | 0.728 | 0.582 | 0.582 | 0.574 | 0.561 | 0.588 | Download |
| ECFP2 fingerprints | 0.834 | 0.919 | 0.826 | 0.871 | 0.779 | 0.914 | 0.967 | 0.907 | 0.930 | 0.882 | Download |
| ECFP4 fingerprints | 0.900 | 0.949 | 0.898 | 0.908 | 0.887 | 0.906 | 0.971 | 0.898 | 0.930 | 0.863 | Download |
| ECFP6 fingerprints | 0.907 | 0.953 | 0.907 | 0.899 | 0.915 | 0.929 | 0.975 | 0.926 | 0.912 | 0.941 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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