Details-Calcnet-AlzheimerNet

Target name

Q13526: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Protein function

Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs in a subset of proteins, resulting in conformational changes in the proteins (PubMed:

Database links

Uniprot primary ID	Q13526
PDB ID	1ZCN 1NMW 2ZQS 4QIB 2ZQV 2ZQU 2ZQT 2ZR6 2XP8 2XP9 2ITK 3JYJ 4U85 2XP3 4U86 2XP6 2XP7 2XP4 2XP5 1I8G 2Q5A 2KBU 1I6C 4TYO 3TCZ 2M8J 2M8I 4GWV 4GWT 3OOB 1PIN 2RUD 2RUC 3IK8 1F8A 1I8H 3I6C 1NMV 3ODK 3KCE 2LB3 3KAC 3KAB 3KAD 3KAG 3NTP 3KAI 3KAH 3KAF 2XPB 2ZR5
DrugBank ID
BioGrid ID	111317
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA33320
KEGG ID	hsa:5300
BioCyc
Entrez Gene (Gene ID)	5300
DIP	DIP-29306N
STRING	9606ENSP00000247970
MINT	MINT-86298
IntAct	Q13526
DMDM	3024406
BREDNA	5218
Rectome	R-HSA-1169408 R-HSA-936440
SignaLink	Q13526
BindingDB	Q13526

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.497	0.464	0.497	0.545	0.457	0.629	0.760	0.698	0.579	0.792	Download
MACCS fingerprints	0.500	0.449	0.491	0.558	0.435	0.634	0.717	0.651	0.684	0.625	Download
Daylight fingerprints	0.506	0.486	0.491	0.571	0.424	0.703	0.719	0.744	0.684	0.792	Download
ECFP2 fingerprints	0.140	0.270	0.272	0.130	0.391	0.606	0.772	0.698	0.526	0.833	Download
ECFP4 fingerprints	0.400	0.365	0.414	0.429	0.402	0.667	0.770	0.721	0.632	0.792	Download
ECFP6 fingerprints	0.456	0.399	0.450	0.506	0.402	0.684	0.770	0.721	0.684	0.750	Download

Download datasets

Positive dataset

Negative dataset