Details-Calcnet-AlzheimerNet

Target name

Q13627: Dual specificity tyrosine-phosphorylation-regulated kinase 1A

Protein function

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6 (By similarity). Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.

Database links

Uniprot primary ID	Q13627
PDB ID	4YLL 2WO6 3ANR 4YLK 4AZE 3ANQ 4YLJ 4NCT 4MQ2 4MQ1 5AIK 4YU2 2VX3
DrugBank ID
BioGrid ID	108192
GuidetoPHARMACOLOGY ID	2009
PharmGKB ID	PA27545
KEGG ID	hsa:1859
BioCyc
Entrez Gene (Gene ID)	1859
DIP	DIP-39750N
STRING	9606ENSP00000381932
MINT	MINT-1205413
IntAct	Q13627
DMDM	3219996
BREDNA	27121
Rectome	R-HSA-1538133
SignaLink	Q13627
BindingDB	Q13627

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.810	0.843	0.810	0.803	0.816	0.803	0.876	0.802	0.803	0.800	Download
MACCS fingerprints	0.798	0.830	0.793	0.807	0.778	0.835	0.859	0.826	0.869	0.783	Download
Daylight fingerprints	0.773	0.815	0.776	0.754	0.799	0.770	0.795	0.769	0.770	0.767	Download
ECFP2 fingerprints	0.761	0.831	0.760	0.758	0.762	0.800	0.895	0.785	0.852	0.717	Download
ECFP4 fingerprints	0.813	0.891	0.822	0.766	0.879	0.852	0.909	0.851	0.852	0.850	Download
ECFP6 fingerprints	0.829	0.876	0.845	0.746	0.946	0.864	0.886	0.868	0.836	0.900	Download

Download datasets

Positive dataset

Negative dataset