Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
| Uniprot primary ID | Q13936 |
| PDB ID | 1T0J 2F3Y 2F3Z 2BE6 2LQC 3OXQ 3G43 |
| DrugBank ID | DB00661 DB00898 DB01054 DB00653 DB01023 DB01115 DB06751 DB04855 DB06712 DB00393 DB00421 DB00622 DB00401 DB00270 DB00381 DB00308 DB04920 DB00568 |
| BioGrid ID | 107229 |
| GuidetoPHARMACOLOGY ID | 529 |
| PharmGKB ID | PA83 |
| KEGG ID | hsa:775 |
| BioCyc | |
| Entrez Gene (Gene ID) | 775 |
| DIP | DIP-29589N |
| STRING | 9606ENSP00000266376 |
| MINT | |
| IntAct | Q13936 |
| DMDM | 308153651 |
| BREDNA | |
| Rectome | R-HSA-400042 R-HSA-419037 R-HSA-422356 |
| SignaLink | |
| BindingDB | Q13936 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.792 | 0.831 | 0.823 | 0.689 | 0.952 | 0.786 | 0.829 | 0.806 | 0.733 | 0.875 | Download |
| MACCS fingerprints | 0.730 | 0.836 | 0.726 | 0.754 | 0.698 | 0.800 | 0.842 | 0.806 | 0.800 | 0.813 | Download |
| Daylight fingerprints | 0.824 | 0.832 | 0.831 | 0.803 | 0.857 | 0.828 | 0.838 | 0.839 | 0.800 | 0.875 | Download |
| ECFP2 fingerprints | 0.746 | 0.835 | 0.742 | 0.770 | 0.714 | 0.828 | 0.900 | 0.839 | 0.800 | 0.875 | Download |
| ECFP4 fingerprints | 0.850 | 0.892 | 0.855 | 0.836 | 0.873 | 0.828 | 0.883 | 0.839 | 0.800 | 0.875 | Download |
| ECFP6 fingerprints | 0.872 | 0.905 | 0.879 | 0.836 | 0.921 | 0.828 | 0.831 | 0.839 | 0.800 | 0.875 | Download |
| Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
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