Target name

Q13936: Voltage-dependent L-type calcium channel subunit alpha-1C

  Protein function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to DHP compounds. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.

  Database links

Uniprot primary ID Q13936
PDB ID 1T0J 2F3Y 2F3Z 2BE6 2LQC 3OXQ 3G43
DrugBank ID DB00661 DB00898 DB01054 DB00653 DB01023 DB01115 DB06751 DB04855 DB06712 DB00393 DB00421 DB00622 DB00401 DB00270 DB00381 DB00308 DB04920 DB00568
BioGrid ID 107229
PharmGKB ID PA83
KEGG ID hsa:775
Entrez Gene (Gene ID) 775
DIP DIP-29589N
STRING 9606ENSP00000266376
IntAct Q13936
DMDM 308153651
Rectome R-HSA-400042 R-HSA-419037 R-HSA-422356
BindingDB Q13936

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.792 0.831 0.823 0.689 0.952 0.786 0.829 0.806 0.733 0.875 Download
MACCS fingerprints 0.730 0.836 0.726 0.754 0.698 0.800 0.842 0.806 0.800 0.813 Download
Daylight fingerprints 0.824 0.832 0.831 0.803 0.857 0.828 0.838 0.839 0.800 0.875 Download
ECFP2 fingerprints 0.746 0.835 0.742 0.770 0.714 0.828 0.900 0.839 0.800 0.875 Download
ECFP4 fingerprints 0.850 0.892 0.855 0.836 0.873 0.828 0.883 0.839 0.800 0.875 Download
ECFP6 fingerprints 0.872 0.905 0.879 0.836 0.921 0.828 0.831 0.839 0.800 0.875 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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