Target name

Q14289: Protein-tyrosine kinase 2-beta

  Protein function

Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca

  Database links

Uniprot primary ID Q14289
PDB ID 3FZP 3FZS 3FZR 3FZT 3H3C 4H1J 3U3F 4H1M 2FO6 3GM1 4EKU 3GM3 3ET7 3CC6 3GM2 4R32 3FZO 2LK4
DrugBank ID DB01097
BioGrid ID 108480
PharmGKB ID PA33956
KEGG ID hsa:2185
Entrez Gene (Gene ID) 2185
STRING 9606ENSP00000332816
MINT MINT-1211326
IntAct Q14289
DMDM 3183003
BREDNA 27102
Rectome R-HSA-4420097 R-HSA-391160 R-HSA-451927
SignaLink Q14289
BindingDB Q14289

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.862 0.917 0.865 0.835 0.896 0.905 0.933 0.918 0.950 0.897 Download
MACCS fingerprints 0.828 0.911 0.824 0.845 0.802 0.818 0.908 0.837 0.900 0.793 Download
Daylight fingerprints 0.871 0.886 0.865 0.907 0.823 0.851 0.897 0.857 1.000 0.759 Download
ECFP2 fingerprints 0.747 0.828 0.751 0.732 0.771 0.792 0.904 0.796 0.950 0.690 Download
ECFP4 fingerprints 0.831 0.911 0.839 0.784 0.896 0.857 0.929 0.878 0.900 0.862 Download
ECFP6 fingerprints 0.831 0.913 0.845 0.763 0.927 0.878 0.938 0.898 0.900 0.897 Download

  Download datasets

Positive dataset Negative dataset

Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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