Details-Calcnet-AlzheimerNet

Target name

Q15078: Cyclin-dependent kinase 5 activator 1

Protein function

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Database links

Uniprot primary ID	Q15078
PDB ID	1UNH 1H4L 1UNL 3O0G 1UNG
DrugBank ID
BioGrid ID	114376
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA26311
KEGG ID	hsa:8851
BioCyc
Entrez Gene (Gene ID)	8851
DIP	DIP-24222N
STRING	9606ENSP00000318486
MINT	MINT-128009
IntAct	Q15078
DMDM	2498217
BREDNA
Rectome	R-HSA-399956
SignaLink	Q15078
BindingDB	Q15078

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.668	0.794	0.732	0.536	0.930	0.708	0.831	0.762	0.580	0.942	Download
MACCS fingerprints	0.779	0.862	0.776	0.786	0.767	0.812	0.890	0.819	0.803	0.835	Download
Daylight fingerprints	0.738	0.746	0.734	0.745	0.723	0.746	0.753	0.739	0.768	0.711	Download
ECFP2 fingerprints	0.788	0.902	0.800	0.739	0.861	0.831	0.934	0.842	0.781	0.902	Download
ECFP4 fingerprints	0.826	0.926	0.839	0.758	0.922	0.847	0.952	0.860	0.781	0.938	Download
ECFP6 fingerprints	0.789	0.908	0.815	0.686	0.946	0.821	0.933	0.842	0.728	0.956	Download

Download datasets

Positive dataset

Negative dataset