Target name

Q16620: BDNF/NT-3 growth factors receptor

  Protein function

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

  Database links

Uniprot primary ID Q16620
DrugBank ID DB00321
BioGrid ID 110970
PharmGKB ID PA31818
KEGG ID hsa:4915
Entrez Gene (Gene ID) 4915
STRING 9606ENSP00000277120
MINT MINT-156841
IntAct Q16620
DMDM 2497560
BREDNA 27101
Rectome R-HSA-187024
SignaLink Q16620
BindingDB Q16620

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.747 0.830 0.769 0.685 0.852 0.741 0.864 0.741 0.625 0.909 Download
MACCS fingerprints 0.776 0.847 0.759 0.833 0.685 0.857 0.909 0.815 0.938 0.636 Download
Daylight fingerprints 0.739 0.760 0.731 0.759 0.704 0.813 0.770 0.778 0.813 0.727 Download
ECFP2 fingerprints 0.552 0.590 0.519 0.593 0.444 0.667 0.872 0.704 0.500 1.000 Download
ECFP4 fingerprints 0.722 0.807 0.750 0.648 0.852 0.720 0.869 0.741 0.563 1.000 Download
ECFP6 fingerprints 0.698 0.828 0.759 0.556 0.963 0.720 0.847 0.741 0.563 1.000 Download

  Download datasets

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Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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