Details-Calcnet-AlzheimerNet

Target name

Q8WW43: Gamma-secretase subunit APH-1B

Protein function

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.

Database links

Uniprot primary ID	Q8WW43
PDB ID
DrugBank ID
BioGrid ID	123659
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA142672600
KEGG ID	hsa:83464
BioCyc
Entrez Gene (Gene ID)	83464
DIP
STRING	9606ENSP00000261879
MINT	MINT-4721718
IntAct	Q8WW43
DMDM	61252592
BREDNA
Rectome	R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096
SignaLink	Q8WW43
BindingDB	Q8WW43

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.886	0.914	0.883	0.901	0.866	0.904	0.913	0.888	0.984	0.778	Download
MACCS fingerprints	0.814	0.869	0.810	0.832	0.787	0.817	0.881	0.810	0.803	0.818	Download
Daylight fingerprints	0.828	0.870	0.840	0.767	0.913	0.921	0.912	0.914	0.935	0.889	Download
ECFP2 fingerprints	0.908	0.944	0.905	0.931	0.879	0.960	0.974	0.957	0.968	0.944	Download
ECFP4 fingerprints	0.933	0.952	0.931	0.961	0.900	0.960	0.986	0.957	0.968	0.944	Download
ECFP6 fingerprints	0.940	0.955	0.940	0.953	0.926	0.960	0.980	0.957	0.968	0.944	Download

Download datasets

Positive dataset

Negative dataset