Details-Calcnet-AlzheimerNet

Target name

Q92731: Estrogen receptor beta

Protein function

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:

Database links

Uniprot primary ID	Q92731
PDB ID	1U9E 1L2J 1ZAF 1X7B 4J24 4J26 1YY4 3OMO 2NV7 2JJ3 1X76 2YJD 2Z4B 3OMQ 3OMP 1X78 2GIU 2I0G 1X7J 2QTU 1YYE 3OLL 1QKM 1U3R 1U3S 2YLY 1U3Q 2FSZ 1NDE 3OLS
DrugBank ID	DB00481 DB04574 DB01108 DB01196 DB04573 DB00783 DB00675 DB00255
BioGrid ID	108404
GuidetoPHARMACOLOGY ID	621
PharmGKB ID	PA27886
KEGG ID	hsa:2100
BioCyc
Entrez Gene (Gene ID)	2100
DIP	DIP-5966N
STRING	9606ENSP00000343925
MINT
IntAct	Q92731
DMDM	6166154
BREDNA
Rectome	R-HSA-383280
SignaLink	Q92731
BindingDB	Q92731

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.758	0.821	0.772	0.713	0.831	0.780	0.839	0.790	0.722	0.863	Download
MACCS fingerprints	0.781	0.845	0.789	0.755	0.822	0.804	0.869	0.801	0.770	0.837	Download
Daylight fingerprints	0.719	0.741	0.720	0.718	0.721	0.726	0.756	0.725	0.706	0.746	Download
ECFP2 fingerprints	0.847	0.913	0.852	0.815	0.889	0.869	0.938	0.871	0.835	0.908	Download
ECFP4 fingerprints	0.869	0.916	0.877	0.816	0.938	0.893	0.936	0.895	0.847	0.947	Download
ECFP6 fingerprints	0.852	0.913	0.864	0.779	0.950	0.876	0.937	0.883	0.806	0.964	Download

Download datasets

Positive dataset

Negative dataset