Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
| Uniprot primary ID | Q9NR96 |
| PDB ID | |
| DrugBank ID | DB00608 DB01611 |
| BioGrid ID | 119902 |
| GuidetoPHARMACOLOGY ID | 1759 |
| PharmGKB ID | PA38010 |
| KEGG ID | hsa:54106 |
| BioCyc | |
| Entrez Gene (Gene ID) | 54106 |
| DIP | |
| STRING | 9606ENSP00000417517 |
| MINT | |
| IntAct | Q9NR96 |
| DMDM | 20140872 |
| BREDNA | |
| Rectome | R-HSA-109704 R-HSA-975138 R-HSA-975110 R-HSA-1679131 R-HSA-975155 R-HSA-168138 |
| SignaLink | |
| BindingDB | Q9NR96 |
| Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.661 | 0.706 | 0.663 | 0.651 | 0.675 | 0.710 | 0.783 | 0.686 | 0.733 | 0.634 | Download |
| MACCS fingerprints | 0.640 | 0.687 | 0.636 | 0.640 | 0.633 | 0.703 | 0.753 | 0.686 | 0.711 | 0.659 | Download |
| Daylight fingerprints | 0.593 | 0.646 | 0.610 | 0.564 | 0.657 | 0.716 | 0.699 | 0.686 | 0.756 | 0.610 | Download |
| ECFP2 fingerprints | 0.542 | 0.539 | 0.519 | 0.564 | 0.473 | 0.740 | 0.798 | 0.698 | 0.822 | 0.561 | Download |
| ECFP4 fingerprints | 0.667 | 0.678 | 0.639 | 0.715 | 0.562 | 0.765 | 0.804 | 0.721 | 0.867 | 0.561 | Download |
| ECFP6 fingerprints | 0.669 | 0.699 | 0.648 | 0.703 | 0.592 | 0.735 | 0.770 | 0.698 | 0.800 | 0.585 | Download |
| Positive dataset | Negative dataset |
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School of Pharmaceutical Sciences, Central South University.
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