Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection.
Uniprot primary ID | Q9NR96 |
PDB ID | |
DrugBank ID | DB00608 DB01611 |
BioGrid ID | 119902 |
GuidetoPHARMACOLOGY ID | 1759 |
PharmGKB ID | PA38010 |
KEGG ID | hsa:54106 |
BioCyc | |
Entrez Gene (Gene ID) | 54106 |
DIP | |
STRING | 9606ENSP00000417517 |
MINT | |
IntAct | Q9NR96 |
DMDM | 20140872 |
BREDNA | |
Rectome | R-HSA-109704 R-HSA-975138 R-HSA-975110 R-HSA-1679131 R-HSA-975155 R-HSA-168138 |
SignaLink | |
BindingDB | Q9NR96 |
Fingerprint type | F1_CV | AUC_CV | Accuracy_CV | Sensitivity_CV | Specificity_CV | F1_test | AUC_test | Accuracy_test | Sensitivity_test | Specificity_test | Download model |
---|---|---|---|---|---|---|---|---|---|---|---|
FP2 fingerprints | 0.661 | 0.706 | 0.663 | 0.651 | 0.675 | 0.710 | 0.783 | 0.686 | 0.733 | 0.634 | Download |
MACCS fingerprints | 0.640 | 0.687 | 0.636 | 0.640 | 0.633 | 0.703 | 0.753 | 0.686 | 0.711 | 0.659 | Download |
Daylight fingerprints | 0.593 | 0.646 | 0.610 | 0.564 | 0.657 | 0.716 | 0.699 | 0.686 | 0.756 | 0.610 | Download |
ECFP2 fingerprints | 0.542 | 0.539 | 0.519 | 0.564 | 0.473 | 0.740 | 0.798 | 0.698 | 0.822 | 0.561 | Download |
ECFP4 fingerprints | 0.667 | 0.678 | 0.639 | 0.715 | 0.562 | 0.765 | 0.804 | 0.721 | 0.867 | 0.561 | Download |
ECFP6 fingerprints | 0.669 | 0.699 | 0.648 | 0.703 | 0.592 | 0.735 | 0.770 | 0.698 | 0.800 | 0.585 | Download |
Positive dataset | Negative dataset |
Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University.
All rights reserved.
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E-mail: biomed@csu.edu.cn
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