Details-Calcnet-AlzheimerNet

Target name

Q9NZ42: Gamma-secretase subunit PEN-2

Protein function

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.

Database links

Uniprot primary ID	Q9NZ42
PDB ID
DrugBank ID
BioGrid ID	120953
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA142671122
KEGG ID	hsa:55851
BioCyc
Entrez Gene (Gene ID)	55851
DIP
STRING	9606ENSP00000222266
MINT	MINT-5207259
IntAct	Q9NZ42
DMDM	37081820
BREDNA
Rectome	R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096
SignaLink	Q9NZ42
BindingDB	Q9NZ42

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.834	0.866	0.823	0.887	0.757	0.788	0.879	0.806	0.867	0.762	Download
MACCS fingerprints	0.815	0.883	0.787	0.930	0.643	0.757	0.871	0.750	0.933	0.619	Download
Daylight fingerprints	0.848	0.864	0.865	0.746	0.986	0.897	0.910	0.917	0.867	0.952	Download
ECFP2 fingerprints	0.726	0.827	0.716	0.746	0.686	0.765	0.924	0.778	0.867	0.714	Download
ECFP4 fingerprints	0.785	0.870	0.794	0.746	0.843	0.839	0.894	0.861	0.867	0.857	Download
ECFP6 fingerprints	0.797	0.869	0.809	0.746	0.871	0.839	0.884	0.861	0.867	0.857	Download

Download datasets

Positive dataset

Negative dataset