Target name

Q9NZ42: Gamma-secretase subunit PEN-2


  Protein function

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.

  Database links

Uniprot primary ID Q9NZ42
PDB ID
DrugBank ID
BioGrid ID 120953
GuidetoPHARMACOLOGY ID
PharmGKB ID PA142671122
KEGG ID hsa:55851
BioCyc
Entrez Gene (Gene ID) 55851
DIP
STRING 9606ENSP00000222266
MINT MINT-5207259
IntAct Q9NZ42
DMDM 37081820
BREDNA
Rectome R-HSA-193692 R-HSA-1980150 R-HSA-1980148 R-HSA-2644606 R-HSA-3928665 R-HSA-205043 R-HSA-2122948 R-HSA-2894862 R-HSA-1251985 R-HSA-2979096
SignaLink Q9NZ42
BindingDB Q9NZ42

  Model Performance Metrics

Fingerprint type F1_CV AUC_CV Accuracy_CV Sensitivity_CV Specificity_CV F1_test AUC_test Accuracy_test Sensitivity_test Specificity_test Download model
FP2 fingerprints 0.834 0.866 0.823 0.887 0.757 0.788 0.879 0.806 0.867 0.762 Download
MACCS fingerprints 0.815 0.883 0.787 0.930 0.643 0.757 0.871 0.750 0.933 0.619 Download
Daylight fingerprints 0.848 0.864 0.865 0.746 0.986 0.897 0.910 0.917 0.867 0.952 Download
ECFP2 fingerprints 0.726 0.827 0.716 0.746 0.686 0.765 0.924 0.778 0.867 0.714 Download
ECFP4 fingerprints 0.785 0.870 0.794 0.746 0.843 0.839 0.894 0.861 0.867 0.857 Download
ECFP6 fingerprints 0.797 0.869 0.809 0.746 0.871 0.839 0.884 0.861 0.867 0.857 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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