Details-Calcnet-AlzheimerNet

Target name

Q9Y5Z0: Beta-secretase 2

Protein function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.

Database links

Uniprot primary ID	Q9Y5Z0
PDB ID	3ZKG 3ZKI 3ZKN 3ZKM 3ZKS 4BFB 3ZKQ 4BEL 2EWY 3ZKX 3ZL7 3ZLQ
DrugBank ID
BioGrid ID	117353
GuidetoPHARMACOLOGY ID	2331
PharmGKB ID	PA25233
KEGG ID	hsa:25825
BioCyc	MetaCyc:G66-33964-MONOMER
Entrez Gene (Gene ID)	25825
DIP
STRING	9606ENSP00000332979
MINT
IntAct
DMDM	6685260
BREDNA	342345
Rectome
SignaLink
BindingDB	Q9Y5Z0

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.843	0.889	0.851	0.799	0.903	0.876	0.921	0.875	0.886	0.864	Download
MACCS fingerprints	0.802	0.925	0.814	0.749	0.881	0.855	0.934	0.857	0.825	0.890	Download
Daylight fingerprints	0.839	0.847	0.833	0.866	0.799	0.865	0.861	0.850	0.964	0.736	Download
ECFP2 fingerprints	0.896	0.938	0.894	0.907	0.882	0.885	0.951	0.879	0.936	0.821	Download
ECFP4 fingerprints	0.897	0.932	0.895	0.911	0.880	0.893	0.926	0.886	0.950	0.821	Download
ECFP6 fingerprints	0.887	0.924	0.885	0.898	0.871	0.878	0.903	0.871	0.929	0.814	Download

Download datasets

Positive dataset

Negative dataset