Details-Calcnet-AlzheimerNet

Target name

P10635: Cytochrome P450 2D6

Protein function

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.

Database links

Uniprot primary ID	P10635
PDB ID	4XRZ 4XRY 3TDA 3TBG 2F9Q 3QM4 4WNU 4WNT 4WNW 4WNV
DrugBank ID	DB00951 DB00950 DB00956 DB01167 DB01166 DB01410 DB00674 DB00810 DB01093 DB08868 DB00818 DB00381 DB04946 DB04868 DB01095 DB04861 DB01096 DB01233 DB00409 DB00703 DB00701 DB00549 DB06204 DB00679 DB00259 DB00540 DB00205 DB00705 DB01115 DB00904 DB01182 DB00571
BioGrid ID	107940
GuidetoPHARMACOLOGY ID
PharmGKB ID	PA128
KEGG ID	hsa:1565
BioCyc
Entrez Gene (Gene ID)	1565
DIP
STRING	9606ENSP00000353820
MINT
IntAct
DMDM	84028191
BREDNA	1149938 114141
Rectome	R-HSA-211999 R-HSA-211981 R-HSA-211935 R-HSA-211958
SignaLink
BindingDB	P10635

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.674	0.763	0.703	0.707	0.700	0.644	0.756	0.682	0.657	0.702	Download
MACCS fingerprints	0.693	0.765	0.725	0.713	0.733	0.720	0.801	0.749	0.726	0.767	Download
Daylight fingerprints	0.640	0.682	0.661	0.694	0.636	0.635	0.661	0.656	0.683	0.636	Download
ECFP2 fingerprints	0.692	0.800	0.738	0.678	0.785	0.701	0.826	0.744	0.686	0.788	Download
ECFP4 fingerprints	0.719	0.816	0.762	0.702	0.808	0.751	0.839	0.787	0.734	0.828	Download
ECFP6 fingerprints	0.708	0.813	0.757	0.679	0.817	0.735	0.833	0.776	0.712	0.825	Download

Download datasets

Positive dataset

Negative dataset