Details-Calcnet-AlzheimerNet

Target name

P28845: Corticosteroid 11-beta-dehydrogenase isozyme 1

Protein function

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

Database links

Uniprot primary ID	P28845
PDB ID	3BYZ 3BZU 4K1L 3HFG 3CH6 1XU9 2BEL 3D4N 3D3E 1XU7 3D5Q 4BB5 4BB6 2IRW 3H6K 4IJW 3OQ1 4IJV 4IJU 3QQP 3FCO 2ILT 3EY4 4HX5 3FRJ 3CZR 2RBE 4C7J 4C7K 3PDJ 3TFQ 4HFR 4P38
DrugBank ID	DB00635
BioGrid ID	109523
GuidetoPHARMACOLOGY ID	2763
PharmGKB ID	PA29476
KEGG ID	hsa:3290
BioCyc	MetaCyc:HS04154-MONOMER
Entrez Gene (Gene ID)	3290
DIP	DIP-59618N
STRING	9606ENSP00000261465
MINT
IntAct	P28845
DMDM	118569
BREDNA	111146 111B40
Rectome	R-HSA-194002
SignaLink
BindingDB	P28845

Model Performance Metrics

Fingerprint type	F1_CV	AUC_CV	Accuracy_CV	Sensitivity_CV	Specificity_CV	F1_test	AUC_test	Accuracy_test	Sensitivity_test	Specificity_test	Download model
FP2 fingerprints	0.823	0.884	0.823	0.820	0.826	0.846	0.908	0.846	0.851	0.841	Download
MACCS fingerprints	0.775	0.855	0.775	0.772	0.778	0.789	0.872	0.791	0.793	0.790	Download
Daylight fingerprints	0.760	0.826	0.786	0.678	0.893	0.771	0.852	0.795	0.689	0.902	Download
ECFP2 fingerprints	0.898	0.961	0.901	0.873	0.929	0.910	0.968	0.912	0.896	0.927	Download
ECFP4 fingerprints	0.906	0.967	0.911	0.863	0.959	0.925	0.975	0.927	0.901	0.952	Download
ECFP6 fingerprints	0.882	0.956	0.890	0.821	0.958	0.908	0.970	0.912	0.862	0.963	Download

Download datasets

Positive dataset

Negative dataset